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Overview
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Novel Drug Modalities
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Related Resources
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Related Services
Overview
Our dedicated R&D team has summarized pharmacokinetic research strategies and established comprehensive evaluation solution from in vitro to in vivo for different novel drug modalities. The team consists of experts in different fields covering in vitro and in vivo ADME, metabolite identification, QWBA and radiolabeled mass balance, and bioanalysis.
We have collaborated with pharmaceutical and biotech companies focusing on new drug modalities. We have successfully supported thousands of projects and conducted extensive testing on tens of thousands of drug molecules, including peptides, antibodies, oligonucleotides, PROTACs, ADCs, PDCs, mRNA, Covalent Drugs, and etc.
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Novel Drug Modalities
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PROTAC DMPK Services
Based on the pharmacokinetics evaluation systems for PROTAC molecules, WuXi AppTec DMPK has supported the screening of tens of thousands of PROTAC molecules and the IND applications of dozens of PROTAC molecules. In this process, we have formed a unique methodology for PROTAC pharmacokinetic studies - aimed at helping drug developers rapidly advance their PROTAC drug development projects.
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ADC (Antibody-Drug Conjugate) DMPK Services
Based on the ADC integrated platform, WuXi AppTec DMPK has supported more than 200 ADCs for screening and more than 20 ADCs for IND filing. Throughout this process, we have accumulated extensive experience and can propose a specific DMPK strategy for each ADC project, which can effectively shorten the ADC development cycle.
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Oligonucleotide Drugs DMPK Services
We have helped more than 70 global clients successfully screen and evaluate oligonucleotide pipelines, and have enabled dozens of oligonucleotide molecules’ IND applications, including ASO, siRNA, miRNA, and more. We not only have extensive experience in studying oligonucleotides but also have developed a specific methodology for the pharmacokinetic study of oligonucleotide drugs.
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Peptide-Drug Conjugate (PDC) DMPK Services
Based on the characteristics of PDCs, the development strategy and assay condition of PDCs are customized according to our experience. WuXi AppTec DMPK has successfully supported more than 20 clients on PDC projects, including some IND-enabling studies.
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Peptide Drugs DMPK Services
Based on the peptide integrated platform, WuXi AppTec DMPK has supported more than 140 global clients on peptide projects, including the screening of tens of thousands of peptide molecules and the IND applications of dozens of peptide molecules.
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mRNA-Based Vaccines and Therapeutics Drugs DMPK Services
To facilitate the research and development of mRNA-based vaccines and therapeutics, WuXi AppTec DMPK has established an integrated bioanalytical platform. This platform includes qPCR, branched DNA (bDNA), ligand binding assays (LBA), liquid chromatography-mass spectrometry (LC-MS), and flow cytometry, enabling quantitative and semi-quantitative analysis of mRNA.
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Covalent Drugs DMPK Services
The mechanism of covalent drugs is different from that of conventional small molecule drugs, which may bring corresponding challenges to the ADME studies, such as distribution and elimination studies. WuXi AppTec DMPK has established ADME platforms specially for covalent drugs. Up to now, WuXi AppTec DMPK has successfully supported nearly 100 covalent drug projects for clients and has successfully pushed many covalent drugs into clinical trials.
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