Comprehensive Characterization of ADC Biotransformation in In Vitro Plasma Using UPLC-HRMS

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June 05,2026

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Here, we develop a UPLC-HRMS workflow to enable rapid, comprehensive profiling of ADC biotransformation in plasma. This approach simultaneously captures intact ADC or subunits, payload-conjugated components, and payload-related metabolites, facilitating stability assessment and mechanistic insight into ADC catabolic routes.

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