Radiolabeled MetID (Metabolite Profiling and Identification)

WuXi AppTec DMPK can provide the service of radiolabeled MetID studies with [¹⁴C] and [³H] labeled compounds in vitro, in animals and human. Experimental assays include but not limited to: metabolic stability and metabolite identification studies in vitro (plasma, liver S9, liver microsomes or hepatocytes of multiple species), and in vivo (mice, rats, dogs, monkeys, and humans). The radiolabeled metabolite identification platform has been applied to various compound types, including conventional small molecules, high-polar and non-polar small molecules, natural products, nucleotides, Proteolysis-Targeting Chimeras (PROTACs*), peptides, ADCs, PDCs, oligonucleotide, etc.; Involved matrix types include blood, plasma, urine, feces, bile, tissues, etc.