ADC Series
ADCs have the characteristics of both small molecule and macromolecular drugs, bringing unique challenges to ADC DMPK research. The ADC series includes DMPK challenges, strategies for ADC payload release and metabolism, bioanalytical strategies, application of radiolabeling techniques in ADC PK studies, and drug conjugate linkers and their effects on drug properties, etc.
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Novel Drug Modalities
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Therapeutic Areas
General Considerations and DMPK Strategies for ADC Drugs
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Preclinical Drug Development Testing for Antibody-Drug Conjugate (ADC)
BrochuresMay 04,2023Learn More
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DMPK Strategies in the Preclinical Development of Antibody-Drug Conjugates
WebinarsMar 25,2024Learn More -
Webinar Q&A | DMPK Strategies in the Preclinical Development of Antibody-Drug Conjugates
BlogsJun 14,2024Learn More -
Drug Conjugate Linkers and Their Effects on Drug Properties
ArticlesAug 10,2023Learn More -
Strategies and Methods for Studying ADC Payload Release and Metabolism
ArticlesJul 13,2023Learn More -
Advancing Antibody-Drug Conjugates (ADCs) with Novel Payloads and Their DMPK Considerations
ArticlesDec 10,2024Learn More -
Antibody-Drug Conjugate (ADC) Preclinical PK/PD Study Strategies and Practices
ArticlesFeb 19,2025Learn More
In Vitro ADME Studies for ADC Therapeutics
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The Strategies and Methods for In-Vitro ADME Characterization of ADCs
WebinarsAug 18,2023 -
Webinar Q&A | The Strategies and Methods for In Vitro ADME Characterization of ADCs
BlogsAug 23,2023 -
In Vitro Metabolic Stability Evaluation of ADCs in Plasma and Whole Blood
PostersOct 17,2024
Bioanalysis for ADC Drugs
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Integrated Bioanalytical Platform Accelerates ADC IND Filing
PostersMay 12,2023 -
In Vitro/Vivo Characterization of ADC Drugs by Immunocapture and High-resolution Mass Spectrometry
PostersMay 19,2023 -
Facilitating ADC Preclinical DMPK Research with an Integrated Bioanalysis Platform
WebinarsMay 24,2024 -
Comprehensive Bioanalysis of ADCs in DMPK Studies
ArticlesAug 10,2023 -
Webinar Q&A | Facilitating ADC Preclinical DMPK Research with an Integrated Bioanalysis Platform
BlogsMay 24,2024 -
Antibody-Drug Conjugate (ADC) Bioanalysis Strategies Based on LC-MS
ArticlesJul 20,2023 -
A Novel Validated LC-MS/MS Approach for Simultaneous Determination of Total Antibody and Conjugated Payload for DS-8201 in SD Rat Serum
PostersAug 08,2024 -
Methodologies and Strategies for ADC Biotransformation Studies
WebinarsJan 15,2025 -
Development of a Rapid, High Throughput Quantitative Bioanalysis Method for Conjugated Payloads of Protease-Cleavable Antibody-Drug Conjugate (ADC) in Rat Serum Using Automated Immuno-Capture Based UPLC-MS/MS
PostersFeb 06,2025 -
Comprehensive Mass Spectrometry Based Bioanalysis Strategy for Antibody-Drug Conjugate Therapeutics
PostersJan 30,2025 -
Streamlining the Bioanalysis of Antibody-Drug Conjugates (ADCs): Simultaneous Determination of Total Antibodies and Conjugated Payloads
ArticlesMar 04,2025
Metabolite Identification (MetID) in ADC Research
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DAR Distribution Determination for Antibody-drug-conjugates (ADCs) by LC-HRMS in In Vitro and In Vivo Studies
PostersOct 27,2023 -
A New Method to Improve Identification of the Payload-Containing Catabolites of ADCs
BlogsAug 10,2023 -
Methodologies and Strategies for ADC Biotransformation Studies
WebinarsJan 15,2025
Radiolabeled ADME Studies for ADC Pharmacokinetics
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Quantitative Whole-body Autoradiography (QWBA) Enables ADC Tissue Distribution Studies in Tumor-bearing Nude Rodents
BlogsAug 18,2023 -
Application of Radiolabeling Techniques in ADC PK Studies
ArticlesJul 26,2023
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