Bioanalytical Strategy for Quantitative Conjugated Payloads of Antibody-Drug Conjugates (ADCs) with Cleavable Linker

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March 12,2025

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Currently, out of sixteen approved ADCs on the global market, 13 ADCs have cleavable linkers, including protease-cleavable linkers, reduction linkers, and pH-sensitive linkers. This study took these three types of cleavable linkers as examples to establish a rapid, high-throughput, sensitive, and reliable liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for conjugated payload quantification, which was successfully applied to in vivo PK rat serum sample analysis.

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