A Novel Validated LC-MS/MS Approach for Simultaneous Determination of Total Antibody and Conjugated Payload for DS-8201 in SD Rat Serum

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August 08,2024

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Trastuzumab deruxtecan (DS-8201), a HER2-targeting antibody-drug conjugate, comprises of an anti-HER2 antibody, a cleavable linker, and a topoisomerase I inhibitor payload, and an enzymatically cleavable peptide-based linker. DS-8201 addresses the limitations of previous-generation ADCs. To learn the DS-8201 actual effect on the disease, the conjugated payload and total antibody in the body should be monitored. Therefore, it is necessary to establish a method for both of them. UPLC-MS/MS is a sensitive platform for peptide and payload analysis. It can be used to detect them simultaneously.

A Novel Validated LC-MS/MS Approach for Simultaneous Determination of Total Antibody and Conjugated Payload for DS-8201 in SD Rat Serum

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