Development of a Rapid, High Throughput Quantitative Bioanalysis Method for Conjugated Payloads of Protease-Cleavable Antibody-Drug Conjugate (ADC) in Rat Serum Using Automated Immuno-Capture Based UPLC-MS/MS

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January 23,2025

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Among the 15 ADC drugs currently on the market, there are 7 ADC drugs with protease-cleavable linkers of which 5 are MC-VC-PABC. The linker of DS-8201 is MC-GGFG which was used in many drugs‘ development. In this study, MC-VC-PABC and MC-GGFG, two protease-cleavable linkers with the highest proportion were used as examples to establish a rapid, high-throughput, sensitive, and reliable conjugated payloads quantification method, which was successfully applied to in vivo PK rat serum sample bioanalysis.

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