Solubility Study

Solubility of compounds has received considerable attention in drug discovery, because it not only plays a key role in gastrointestinal absorption of drugs, oral bioavailability, accurate in vitro bioassays, and selection of appropriate dosage forms for in vivo experiments, but also is one of the important parameters in the establishment of biopharmaceutical BCS classification system. During drug discovery, compounds with insufficient solubility often appear. The issue of insufficient solubility of compounds can be solved by using new solvent formulations or delivery systems. However, this can lead to increased development costs and cycle delays and does not guarantee the druggability of the compounds. If the only candidate compound for development has low solubility, thus, early solubility analysis can at least be provided as an early warning for difficulties.

Different types of solubility data are required to characterize compound properties in different research and development stages. In the early stage of research and development, kinetic solubility is one of the important methods for compound sequencing due to the large number of screening assays and the small amount of compound. As compounds enter the later stage, different crystal forms are usually selected for the study, and the thermodynamic solubility test is a commonly used method in this stage. WuXi AppTec DMPK provides two high-throughput screening methods for solubility measurement.