An Integrated In Vitro DMPK Evaluation Strategy for Preclinical ADC Assessment

Posters
July 17,2026

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Linker and payload properties determine ADC in vivo efficacy and off-target toxicity; a unified multi-dimensional in vitro DMPK platform can characterize ADC circulatory safety and payload release responsive to intended triggers (e.g., tumor microenvironment, cellular internalization, enzymatic cleavage) to predict druggability at early stages and reduce in vivo research failure risks.

An Integrated In Vitro DMPK Evaluation Strategy for Preclinical ADC Assessment.jpg

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