Human Subcutaneous PK Prediction For Semaglutide: Applying Wajima Normalization and Allometric Scaling With a Lowered Ka Assumption

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October 13,2026

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This Wajima informed workflow—combining allometric CL/Vss scaling, normalization by MRT/Css, minipig based IV reconstruction, compartmental fitting, and conservative Ka down scaling—provides a pragmatic preliminary validation for predicting human SC PK of semaglutide for early risk assessment and first in human planning. This approach can also be used to predict human PK parameters for semaglutide-like compounds using preclinical animal pharmacokinetics data.

Human Subcutaneous PK Prediction For Semaglutide Applying Wajima Normalization and Allometric Scaling With a Lowered Ka Assumption.jpg

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