Rapid Profiling and Characterization of Payload-Related Catabolites Derived from ADCs in In Vitro Model by HRMS

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June 02,2026

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In this study, we developed a quadrupole–Orbitrap HRMS workflow for rapid screening and structural characterization of payload‑related catabolites derived from ADCs. The workflow was evaluated using two commercially successful ADCs (DS-8201a and SGN‑35) as models, incubated in human plasma and liver lysosomes. Successful screening and characterization of multiple payload‑related catabolites from each incubation validated the approach.

Rapid Profiling and Characterization of Payload-Related Catabolites Derived from ADCs in In Vitro Model by HRMS

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