An Integrated LC-HRMS Workflow for In Vitro Metabolite Identification of Therapeutic Oligonucleotides Using Inclisiran as a Model Compound

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July 17,2026

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The proposed Oligo MetID workflow enabled systematic detection and annotation of inclisiran metabolites while simplifying data processing and interpretation. The observed metabolic profile was consistent with the established nuclease-mediated degradation pathways of chemically modified siRNAs, supporting the utility of the workflow for preclinical metabolism studies and the characterization of therapeutic oligonucleotides.

An Integrated LC-HRMS Workflow for In Vitro Metabolite Identification of Therapeutic Oligonucleotides Using Inclisiran as a Model Compound

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