In Vitro Metabolite Characterization of an Anti-TFR1 Antibody-siRNA Conjugate in Mouse Serum Through Total Oligonucleotide Analysis Following Proteinase K Digestion

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September 01,2026

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Antibody–oligonucleotide conjugates (AOCs) represent a transformative therapeutic modality for targeted extra-hepatic delivery of oligonucleotide therapeutics, yet their efficacy fundamentally depends on maintaining molecular integrity in systemic circulation prior to reaching the target tissue. In vitro serum stability assessment therefore constitutes a critical component of AOC characterization.

In Vitro Metabolite Characterization of an Anti-TFR1 Antibody-siRNA Conjugate in Mouse Serum Through Total Oligonucleotide Analysis Following Proteinase K Digestion.jpg

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