Canine Segmental Intestinal Cannulation Model for Assessing Peptide Absorption: Validation and Application of a Duodenal Cannulation Model Using Octreotide
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Posters
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July 17,2026
Posters Overview
Oral peptide drug absorption is limited by the triple barrier of gastric degradation, intestinal enzymatic hydrolysis, and poor permeability. Conventional models fail to distinguish absorption contributions from different intestinal segments, thereby falling to pinpoint the rate‑limiting sites. Dogs are the preferred model for studying intestinal peptide absorption due to their high similarity to humans in gastrointestinal anatomy, pH gradient, and enzyme profiles. In this study, we established and validated a canine duodenal cannulation model to enables direct perfusion of a specific intestinal segment, bypassing gastric interference and accurately quantifying the segment's intrinsic absorptive capacity.
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