Magnetic Solid-phase Extraction for LC-MS/MS Analysis of GalNAc-Conjugated Oligonucleotides in Plasma and Urine

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February 10,2026

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Consequently, sample preparation typically relies on liquid-liquid extraction (LLE) or solid-phase extraction (SPE). LLE offers operational simplicity and low cost but is prone to pronounced matrix effects, particularly in tissue homogenates and excretory matrices (e.g., urine, bile). In contrast, SPE provides broad applicability across diverse biological matrices yet involves greater operational complexity and higher cost. Herein, we developed a new sample pretreatment method of magnetic-solid phase extraction (mSPE), which offered advantages over LLE and SPE in terms of sample cleanliness, operational simplicity, and cost-effectiveness.

MS-Analysis-of-GalNAc-Conjugated-Oligonucleotides-in-Plasma-and-Urine.jpg

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