An Integrated Mass Spectrometry-Based Platform for the Multiplexed Quantification of Antibody-Oligonucleotide Conjugates (AOCs)

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June 05,2026

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By exploiting the antigen-binding specificity of antibodies, AOCs enable precise delivery of oligonucleotide payloads to tissues and cells that are difficult to reach with conventional oligonucleotide therapies, thereby expanding the therapeutic landscape to rare muscular diseases, cancers, and central‑nervous‑system disorders. It is crucial to characterize the ADME properties of AOCs to optimize their distribution in target tissues and to understand their PK/PD properties. However, the complexity of the AOC structure presents significant challenges for bioanalysis. In this study, we established an integrated mass spectrometry platform to support the bioanalysis of AOCs drug.

An-Integrated-Mass-Spectrometry-Based-Platform-for-the-Multiplexed-Quantification-of-Antibody-Oligonucleotide-Conjugates-(AOCs).jpg

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