Evaluation of Rat Liver Tritosomes as an In Vitro Lysosomal Model for the Catabolism and Payload Release of an Anti-TfR1 Antibody-siRNA Conjugate

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July 10,2026

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Rat liver tritosomes serve as a highly effective and viable in vitro tool for elucidating the complex lysosomal catabolism and payload release mechanisms of AOCs. However, considering potential enzymatic differences between hepatic and extra-hepatic lysosomes, future in vivo studies in target tissues are essential to establish a reliable in vitro-in vivo correlation (IVIVC) and to fully validate the predictive translational value of this model.

Evaluation-of-Rat-Liver-Tritosomes-as-an-In-Vitro-Lysosomal-Model-for-the-Catabolism-and-Payload-Release-of-an-Anti-TfR1-Antibody-siRNA-Conjugate.jpg

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