The Application of Non-Human Primate Liver Biopsy Technique in Preclinical Pharmacokinetic Studies of Oligonucleotide Therapies

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July 17,2026

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Liver-targeted oligonucleotide therapy requires direct quantification of hepatic drug exposure, yet conventional terminal sampling precludes longitudinal monitoring and consumes large numbers of animals. We developed an ultrasound‑guided percutaneous repeat liver biopsy technique in cynomolgus monkeys that enables repeated tissue collection from the same individual over extended periods.

The Application of Non-Human Primate Liver Biopsy Technique in Preclinical Pharmacokinetic Studies of Oligonucleotide Therapies.jpg

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