Screening Strategies for Cyclic Peptide Drugs Based on Structural Characteristics and In Vivo Pharmacokinetics Validation

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July 17,2026

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In this experiment, octreotide was used as the test compound. The mechanism of its metabolism in intestinal fluid was evaluated through in vitro simulated intestinal fluid stability studies, and the effect of vehicles containing different permeation enhancers on the bioavailability of the test compound was verified in vivo using a rat duodenal animal model. The experimental results indicate that the degradation of octreotide in intestinal fluid exhibits significant pancreatin dependence.

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