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Comparative Metabolism of a GalNAc-Conjugated siRNA, Inclisiran, Among Various In Vitro Systems and Correlations with In Vivo Metabolism in Rats

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Comparative Metabolism of a GalNAc-Conjugated siRNA, Inclisiran, Among Various In Vitro Systems and Correlations with In Vivo Metabolism in Rats

GalNAc-conjugated small interfering RNAs (siRNAs) have emerged as a promising new class of therapeutics, demonstrating potential across various disease areas. Metabolic stability is a critical factor in the development of siRNA therapies, necessitating the selection of suitable in vitro metabolism models for comprehensive studies. However, many existing in vitro models often fail to accurately predict in vivo metabolism. Therefore, our objective was to systematically identify the optimal models and conditions that can simulate in vivo metabolism.
May 08, 2025
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WuXi AppTec DMPK: Your Trustworthy Partner

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WuXi AppTec DMPK: Your Trustworthy Partner

WuXi AppTec DMPK proudly serves over 1,600 clients worldwide, supporting over 1,500 IND submissions. We are committed to delivering higher-quality data, more precise development strategies, and exceptional services.
Dec 27, 2024
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Conferences

25th North American ISSX Meeting Program

  • Chicago, IL
  • September 21-24, 2025
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73rd ASMS Conference on Mass Spectrometry and Allied Topics

  • Baltimore Convention Center, Baltimore, Maryland
  • June 1 - 5, 2025
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