Development of Auto-immunocapture based Integrated Mass Spectrometry Platform for Qualitative and Quantitative Study of Fusion Protein Drug

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February 10,2026

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Therapeutic peptide drugs demonstrate significant clinical potential due to their high specificity, strong target affinity, and superior tissue permeability. However, their short half-life often leads to rapid systemic clearance. To overcome these limitations, several strategies have been developed to prolong half-life and enhance efficacy, such as Fc-fusion and antibody conjugation, and so on. In particular, with the increasing application of GLP-1-based fusion proteins in treating obesity and diabetes, understanding and optimizing their pharmacokinetic properties is essential.

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