C&EN Webinars | CNS DMPK Strategies to Improve Brain-Targeted Drug Success

This webinar reviews practical DMPK strategies to increase the likelihood of success for CNS-directed therapeutics. We will cover key properties governing blood–brain barrier (BBB) penetration, methods to assess free brain and plasma exposure, and approaches to minimize efflux and metabolic liabilities while preserving safety margins.

Real-case examples will illustrate problem-solving workflows and risk-mitigation tactics for CNS programs.

Learning Objectives:

• Understand physicochemical and biological determinants of BBB penetration and brain free fraction.

• Learn experimental and modeling approaches to measure and predict brain/plasma exposure and unbound concentrations.

• Apply DMPK-led strategies to reduce efflux, metabolic clearance, and off-target exposure while improving translational PK/PD.