Evaluation of Probe Substrates and Inhibitors for Human CES Enzymes and Their Applications for Plasma Stability Assessment

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August 18,2026

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Carboxylesterases (CES) are major hydrolase enzymes involved in the metabolism of numerous therapeutic agents and prodrugs, making reliable probe substrates and selective inhibitors for CES enzymes critical tools for evaluating CES-mediated drug metabolism and potential drug-drug interactions. While CES enzymes have been extensively studied, the substrate and inhibitor selectivity of human CES isoforms, as well as their utility in plasma stability assessments across species, remain incompletely understood.

Evaluation of Probe Substrates and Inhibitors for Human CES Enzymes and Their Applications for Plasma Stability Assessment.jpg

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