In Vitro Investigation of Drug-Induced Liver Injury Using Radiolabeled Compounds

Posters
July 17,2026

Posters Overview

The CVB Burden and CVB values obtained from in vitro incubations, along with comparison to the positive control [¹⁴C]Clozapine, indicated that [¹⁴C]LS002 exhibited a high-level of covalent binding in the liver and suggested a potential risk of liver injury in clinical use. The result demonstrated that we have established a method using radiolabeled compounds to evaluate covalent binding levels after in vitro incubation. This method can indicate DILI risk, supporting both early drug screening and clinical risk assessment.

In Vitro Investigation of Drug-Induced Liver Injury Using Radiolabeled Compounds (1).jpg

Complete the form to view and download this poster.

First name *

* Please check the filled content
Last name *

* Please check the filled content
Email address *

* Please check the filled content
Phone number
Company *

* Please enter a valid e-mail address
Department *

* Please check the filled content
Country/District *

* Please check the filled content
Position *

* Please check the filled content
City *

* Please check the filled content
Focus area (Service you are interested in)

I want to receive the latest news, insights, and communication from WuXi AppTec DMPK. I understand that I can unsubscribe at any time.

I acknowledge and agree that WuXi AppTec DMPK may transfer my personal information across borders for the purpose of providing products and services through resources worldwide.

By clicking submit below, you consent to WuXi AppTec DMPK collecting and processing the information you provide for our internal purposes, in accordance with our privacy policy.

* Please agree to the Privacy Policy
Submit

Stay Connected

Keep up with the latest news and insights.

Email address*

* Please check the filled content
First name*

* Please check the filled content
Last name*

* Please check the filled content
Company*

* Please check the filled content

By clicking submit, you consent to WuXi AppTec DMPK collecting and processing the information you provide for our internal purposes, in accordance with our privacy policy.

* Please agree to the Privacy Policy

Submit