Establishment of an MDCK II-Based In Vitro Model for Screening Rat Bcrp Substrates and Inhibitors

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July 17,2026

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The newly established hBCRP/rBcrp-MDCK II cell models provide a validated and reproducible platform for screening potential human BCRP and rat Bcrp substrates and inhibitors, enabling the comparison of species-specific transport activity and supporting the interpretation of preclinical pharmacokinetic data for translational applications.

Establishment of an MDCK II-Based In Vitro Model for Screening Rat Bcrp Substrates and Inhibitors.jpg

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