Application of Multiple Fragmentation Nodes for Metabolite Characterization: Exploring Orbitrap HCD, ZenoTOF CID, and Expanded EAD

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July 17,2026

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Structural elucidation of complex modalities (e.g., PROTACs) and labile metabolites (e.g., acyl glucuronides) remains a significant challenge in drug metabolism and pharmacokinetics (DMPK). Traditional collision-induced dissociation (CID) and higher-energy collisional dissociation (HCD) often struggle with large multifaceted molecules and lead to the neutral loss of labile moieties, complicating the precise localization of metabolism sites. This study explores the integrated application of conventional fragmentation methods and the expanded electron activated dissociation (EAD) technology on the new ZenoTOF 8600 system, aiming to establish a robust and complementary workflow for metabolite identification (MetID).

Application of multiple fragmentation modes for metabolite characterization exploring Orbitrap HCD, ZenoTOF CID, and Expanded EAD.jpg

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