A Sensitive and Simple LC-MS/MS Method for Simultaneous Determination of GABA and GHB in Plasma

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May 17,2026

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γ-Aminobutyric acid (GABA) and γ-hydroxybutyric acid (GHB) are key neurotransmitters involved in various neurological disorders, with interconvertible metabolic pathways in humans. Simultaneous quantification of these two analytes is critical for evaluating drug efficacy and safety during preclinical drug discovery. However, their high polarity complicates retention in reverse-phase liquid chromatography, typically necessitating derivatization or HILIC mode.

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