Rapid Determination of Plasma Protein Binding and Dissociation Kinetics Using Dextran-Coated Charcoal Method Assessment and Optimization for Unstable and Highly Bound Compounds

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June 09,2026

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Traditional methods for determining plasma protein binding (PPB), such as equilibrium dialysis and ultracentrifugation, often require lengthy experimental times, limiting their utility for compounds that undergo rapid chemical degradation in plasma. The Dextran-Coated Charcoal (DCC) method offers a kinetic-based, non-equilibrium alternative that is rapid and requires no specialized equipment. This study aimed to systematically assess the applicability, limitations, and potential optimizations of the DCC method across a diverse panel of compounds.

Rapid-Determination-of-Plasma-Protein-Binding-and-Dissociation-Kinetics-Using-Dextran-Coated-Charcoal-Method-Assessment-and-Optimization-for-Unstable-and-Highly-Bound-Compounds.jpg

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