Optimizing Preclinical Pharmacokinetic Studies: A High Throughput Approach for Assessing Brain Drug Exposure
-
Posters
-
July 10,2026
Posters Overview
Preliminary experiments in our laboratory, using male Sprague Dawley (SD) rats (n = 3, body weight: 250 g) for the brain slice method, brain homogenate method, and microdialysis, consistently demonstrated that the brain slice method aligns with the gold-standard microdialysis technique in measuring the unbound brain-to-plasma partition coefficient (Kp,uu). Specifically, carbamazepine (5 mg/kg intravenous dose) yielded a Kp,uu value of 0.86 via the brain slice method versus 0.68 via microdialysis. In contrast, the traditional homogenate method yields significantly lower values than the gold standard value (0.47).
Complete the form to view and download this poster.
Stay Connected
Keep up with the latest news and insights.
