Development of an Automated Integrated Mass Spectrometry Platform for Qualitative and Quantitative Study of Peptide-Fc Fusion Protein

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May 29,2026

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In this study, we established an integrated mass spectrometry platform for the comprehensive characterization of fusion proteindrugs, with various automation method applied in the immunocapture, SPE and data processing steps. For example,magnetic SPE (mSPE) beads can overcome the shortcomings of clogging and complicated operation associated with traditional SPE cartridges. Theymake the purification and concentration process simple, fast, and automation-compatible.Compared with traditional SPE,mSPEincreases efficiency by more than 30% and reduces costs by over 50%.

Development of an Automated Integrated Mass Spectrometry Platform for Qualitative and Quantitative Study of Peptide-Fc Fusion Protein

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