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ISSX: 16th European Meeting | From Benchside Research to Bedside Reality: DMPK's Next Chapter

  • June 29 - July 2

  • Basel, Basel-Stadt, CH

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The 16th European ISSX Meeting will explore how advances in DMPK are transforming benchside research into bedside reality, shaping the next chapter of drug discovery and development.

The scientific program spans innovative experimental systems, AI/ML, model-informed drug development, specific populations, and the ADME challenges of emerging therapeutic modalities, complemented by Drug Discovery and Development Tales that reveal the real-world decisions, setbacks, and breakthroughs behind successful medicines.

A dedicated debate will challenge the community to reflect on whether the future of DMPK will be driven primarily by data-centric AI approaches or by curiosity-driven scientific discovery.

We will be located at booth No. To Be Determined.

Our posters

Other Resources

  • Our posters
  • Other Resources
    • Evaluation of Rat Liver Tritosomes as an In Vitro Lysosomal Model for the Catabolism and Payload Release of an Anti-Tfr1 Antibody-siRNA Conjugate

      Rat liver tritosomes serve as a highly effective and viable in vitro tool for elucidating the complex lysosomal catabolism and payload release mechanisms of AOCs. However, considering potential enzymatic differences between hepatic and extra-hepatic lysosomes, future in vivo studies in target tissues are essential to establish a reliable in vitro-in vivo correlation (IVIVC) and to fully validate the predictive translational value of this model.

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    • Optimizing Preclinical Pharmacokinetic Studies: A High Throughput Approach for Assessing Brain Drug Exposure

      Preliminary experiments in our laboratory, using male Sprague Dawley (SD) rats (n = 3, body weight: 250 g) for the brain slice method, brain homogenate method, and microdialysis, consistently demonstrated that the brain slice method aligns with the gold-standard microdialysis technique in measuring the unbound brain-to-plasma partition coefficient (Kp,uu). Specifically, carbamazepine (5 mg/kg intravenous dose) yielded a Kp,uu value of 0.86 via the brain slice method versus 0.68 via microdialysis. In contrast, the traditional homogenate method yields significantly lower values than the gold standard value (0.47).

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    • The Impact of Probe Substrate Selection on Reducing Off-Target Effects in Enzyme Phenotyping of Slow-Metabolizing Drugs

      For the reaction phenotyping of slow-metabolizing compounds requiring high HLM concentrations or longer reaction times, amodiaquine is no longer suitable. Paclitaxel serves as a superior CYP2C8 probe substrate. Its use enables the assay to be performed under lower inhibitor concentrations, effectively minimizes off-target effects, and ensures the accurate identification of primary metabolic enzymes in drug metabolism studies.

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    • Rapid Determination of Plasma Protein Binding and Dissociation Kinetics Using Dextran-Coated Charcoal (DCC): Method Assessment and Optimization for Unstable and Highly Bound Compounds

      Traditional methods for determining plasma protein binding (PPB), such as equilibrium dialysis and ultracentrifugation, often require lengthy experimental times, limiting their utility for compounds that undergo rapid chemical degradation in plasma. The Dextran-Coated Charcoal (DCC) method offers a kinetic-based, non-equilibrium alternative that is rapid and requires no specialized equipment. This study aimed to systematically assess the applicability, limitations, and potential optimizations of the DCC method across a diverse panel of compounds.

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    • Development of an Efficient LC-MS/MS Method for Simultaneous Analysis of GABA and GHB in Plasma

      γ-Aminobutyric acid (GABA) and γ-hydroxybutyric acid (GHB) are key neurotransmitters involved in various neurological disorders, with interconvertible metabolic pathways in humans. Simultaneous quantification of these two analytes is critical for evaluating drug efficacy and safety during preclinical drug discovery. However, their high polarity complicates retention in reverse-phase liquid chromatography, typically necessitating derivatization or HILIC mode.

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