Validation and Comprehensive Bioanalytical Strategy of In Vivo Studies for RNAI Therapeutics in Early Discovery

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September 13,2024

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The goal of this study was to establish a comprehensive bioanalytical methods to speed up the early discoveryof RNAi therapeutics. This strategy provides appropriate bioanalytical solutions to support in vivo studies for lead compound selection, such as biotransformation, pharmacodynamics (PD) and pharmacokinetics (PK) of small interference RNA (siRNA), and pharmacokinetics of RNA-induced silencing complex (RISC) loading siRNA.

Validation and Comprehensive Bioanalytical Strategy of In Vivo Studies for RNAI Therapeutics in Early Discovery

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