Application of a Rapid Inhibitor-based Human Hepatocyte Screening Assay for Early Identification of Metabolic Pathways

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July 17,2026

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Human hepatocytes represent the optimal in vitro metabolism model as they express the comprehensive complement of drug-metabolizing enzymes. However, identifying the specific enzyme(s) driving the clearance of a drug candidate within this complex system remains challenging. Elucidating these pathways early in the lead optimization phase is crucial for predicting human clearance and mitigating drug-drug interaction (DDI) risks.

Application of a Rapid Inhibitor-based Human Hepatocyte Screening Assay for Early Identification of Metabolic Pathways.jpg

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