A Comparative Study on Cerebrospinal Fluid Blood Contamination Assessment Methods: From Visual Screening to Precise Quantification

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July 17,2026

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Cerebrospinal fluid (CSF) drug concentration is a core metric for evaluating central nervous system drug exposure and blood–brain barrier (BBB) permeability (K_p,uu). However, since large molecule drugs exhibit extremely low BBB permeability, a substantial concentration gradient between blood and CSF is formed, and even minor blood contamination can severely skew the data. Therefore, assessment and correction of CSF sample contamination are critical. This study systematically compared the performance of three blood contamination detection methods: visual inspection, ultraviolet spectrophotometry, and lactate dehydrogenase (LDH) enzymatic method.

A Comparative Study on Cerebrospinal Fluid Blood Contamination Assessment Methods From Visual Screening to Precise Quantification.jpg

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