A Novel Derivatization Procedure for Chemicals with Carboxylic Acid and Its Application in LC-MS/MS Bioanalysis

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April 08,2026

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This work presents a simple, rapid, and broadly applicable derivatization procedure for compounds containing carboxylic acid functional groups. Unlike conventional derivatization approaches that require liquid–liquid extraction, harsh reaction conditions, or specialized solvents, the described method utilizes a straightforward protein precipitation workflow, ambient reaction conditions, commonly used bioanalytical solvents, and significantly reduced reagent consumption. The procedure is readily implementable using standard bioanalytical laboratory equipment without additional training, making it suitable for routine bioanalysis.

A Novel Derivatization Procedure for Chemicals with Carboxylic Acid and Its Application in LC-MS/MS Bioanalysis

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