ISSX: 27th North American Meeting | Back to the Future: DMPK Foundations and New Concepts

The 27th North American ISSX Meeting, Back to the Future: DMPK Foundations and New Concepts, will examine how core DMPK principles continue to inform—and evolve alongside—emerging scientific approaches in drug discovery and development.

The scientific program spans artificial intelligence and machine learning in ADME research, advances in drug–drug interaction assessment, mechanistic and systems pharmacology modeling, and real-world case studies highlighting unexpected biotransformations. Additional sessions explore innovative strategies for treating neurodegenerative diseases, pharmacogenetic drivers of drug toxicity, long-acting medicines, structure-based ADME, and the evolving landscape of obesity therapeutics.

Complementing the symposia, in-depth short courses will address microphysiological systems, in vitro–in vivo extrapolation, DMPK characterization of biologics, and emerging insights into extrahepatic metabolism, offering attendees both foundational knowledge and forward-looking perspectives on the future of DMPK.