Conferences

The 26th International Symposium on Microsomes and Drug Oxidations

May 30, 2026-June 3, 2026
Hong Kong, Hong Kong, HK

The Microsomes and Drug Oxidations (MDO) meeting has connected global drug metabolism and disposition researchers since 1968. Over nearly six decades, MDO has provided an international forum to exchange scientific advances across academia, industry, and regulatory science.

Featured Presentations

Radiolabeling Strategies and ADME Applications for New Modality Molecules

Radiolabeling techniques are extensively applied in vitro and in vivo animal ADME studies and human mass balance studies of new drugs. For novel modalities including peptides, oligonucleotides, and ADCs, a thorough understanding of their absorption, distribution, metabolism, and excretion (ADME) is equally essential during drug development to support clinical trials or regulatory approval. This presentation will cover three areas:

Current industry practices in radiolabeledsynthesis and ADME profiling.
Case studies in preclinicaland clinical stages.
Lessons learned from recent new modality projects, which illustrate practical challenges and solutions in study design, execution, and data interpretation.

DMPK Strategies in the Preclinical Development of Antibody Oligonucleotide Conjugate (AOC) Therapeutics

This presentation aims to share key considerations for formulating DMPK strategies during the preclinical development of AOC therapeutics. Key takeaways will include:

Distinct DMPK challenges presented by AOC molecules.
Key preclinical DMPK strategies to support AOC development.
Platform experience and capabilities of WuXi AppTec DMPK in advancing AOC therapeutics.

Advancing In Vitro Metabolic Models for Oligonucleotide Therapeutics

Metabolic stability is crucial for developing oligonucleotide therapies, necessitating the selection of appropriate in vitro metabolic models for comprehensive studies. This talk will discuss the limitations of current systems and present our research aimed at identifying optimal models and conditions that effectively simulate in vivo metabolism. These optimized models will improve metabolic stability assessment and metabolite identification, facilitating the advancement of oligonucleotide therapeutics.

Speakers

Dr. Lingling Zhang

Dr. Lingling Zhang is currently a Senior Director in the DMPK Department at WuXi AppTec. She specializes in radiolabeled synthesis and ADME studies to advance the development of novel drug candidates, including small molecules, peptides, ADCs, and oligonucleotides. With over 16 years of industry experience, Dr. Zhang has contributed to the approval of dozens of new drugs. She holds more than 10 patents, has authored 7 peer-reviewed publications, and participated in drafting the NMPA guidance on Human Radiolabeled Mass Balance Studies.

Dr. Xiaoqi Wang

Dr. Xiaoqi Wang completed her undergraduate studies in Chemistry at Nanjing University and later earned her PhD from Rutgers University, specializing in the metabolic pathways of small molecules and related PK/PD research. Before joining WuXi AppTec DMPK, she gained valuable experience in antibody analytics within the CMC field. This unique cross-disciplinary background enables her to address the unique DMPK challenges of complex bioconjugates. In her current role as a study director, she specializes in designing and overseeing pharmacokinetic studies for novel therapeutic modalities, with a particular focus on oligonucleotides, AOCs, and ADCs.

Dr. Hong Zhang

Dr. Hong Zhang is a principal expert in the DMPK Department at WuXi AppTec, where he leads a specialized metabolite identification (MetID) group. Bringing over a decade of experience in preclinical drug development, he specializes in optimizing in vitro metabolic systems and elucidating the metabolic profiles of complex novel modalities, including oligonucleotides, antibody-oligonucleotide conjugates (AOCs), and PROTACs, using advanced LC-HRMS techniques.

Our posters

Other Resources

Our posters
Other Resources

- Methodological Comparison of Microsomal Protein Binding: Equilibrium Dialysis, Pre‑Saturation, and Flux Dialysis for Highly Bound Compounds
  
  Liver microsomes, containing key drug-metabolizing enzymes, are widely used in vitro for enzyme kinetic studies. Accurate estimation of kinetic parameters is often influenced by nonspecific binding of test compounds to microsomal proteins and membrane lipids, making determination of the free fraction (f_u) critical for correcting binding-related biases. This study evaluated the performance of three methods—equilibrium dialysis, pre-saturation dialysis, and flux dialysis—across three microsomal protein concentrations (0.1, 0.5, and 1.0 mg/mL) using 13 highly bound compounds. The study also examined how equilibration time and protein stability during incubation affect fu results.
  
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- Rapid Profiling and Characterization of Payload-Related Catabolites Derived from ADCs in In Vitro Model by HRMS
  
  In this study, we developed a quadrupole–Orbitrap HRMS workflow for rapid screening and structural characterization of payload‑related catabolites derived from ADCs. The workflow was evaluated using two commercially successful ADCs (DS-8201a and SGN‑35) as models, incubated in human plasma and liver lysosomes. Successful screening and characterization of multiple payload‑related catabolites from each incubation validated the approach.
  
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The 26th International Symposium on Microsomes and Drug Oxidations