Conferences
74th ASMS Conference on Mass Spectrometry and Allied Topics
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May 31 - June 4, 2026 | Short Courses May 30 & 31
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San Diego, California, US
The American Society for Mass Spectrometry (ASMS) was formed in 1969 to promote and disseminate knowledge of mass spectrometry and allied topics. Membership includes over 8,500 scientists involved in research and development. Members come from academic, industrial and governmental laboratories. Their interests include advancement of techniques and instrumentation in mass spectrometry, as well as fundamental research in chemistry, geology, forensics, biological sciences and physics.
ASMS sponsors the Annual Conference on Mass Spectrometry and Allied Topics that is attended by more than 6,500 scientists. Over 3,000 papers are presented as posters and talks.
Our posters
Other Resources
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Our posters -
Other Resources
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Application of Inductively Coupled Plasma Mass Spectrometry (ICP-MS) for Detecting Metal Nanomaterials in Biological Matrices
Compared with traditional delivery systems, metal nanoparticles (MNPs), including magnetic iron oxide NPs, nanocrystalline silver, gold NPs, platinum NPs, and manganese dioxide NPs, offer significant advantages such as enhanced stability, prolonged circulation time, improved distribution, and precise targeting capability. MNPs exhibit remarkable versatility in surface modification, enabling customization for diverse biomedical applications. By conjugating functional groups (e.g., polymers, peptides, or targeting ligands) to their surfaces, MNPs can achieve site-specific drug delivery.
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Elimination of ADC-Related Interferences for the Detection of Free Payloads in Biological Matrices with LC-MS/MS
Improved pretreatment methods for the elimination of ADC-related interferences are introduced in the study, which were applied for the detection of free payloads including MMAE, DXD, Exatecan, and Payload 1.
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Magnetic-Solid Phase Extraction for LC-MS/MS Analysis of GalNAc-Conjugated Oligonucleotides in Plasma and Urine
Consequently, sample preparation typically relies on liquid-liquid extraction (LLE) or solid-phase extraction (SPE). LLE offers operational simplicity and low cost but is prone to pronounced matrix effects, particularly in tissue homogenates and excretory matrices (e.g., urine, bile). In contrast, SPE provides broad applicability across diverse biological matrices yet involves greater operational complexity and higher cost. Herein, we developed a new sample pretreatment method of magnetic-solid phase extraction (mSPE), which offered advantages over LLE and SPE in terms of sample cleanliness, operational simplicity, and cost-effectiveness.
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A Robust LC-MS/MS Method for Determination of Schiff-Base Forming Reversible Covalent Inhibitors in Whole Blood
Covalent inhibitors are small molecules that bind to target proteins via covalent bonds, enhancing inhibitory activity. They are classified as reversible or irreversible inhibitors based on bond type. Voxelotor, a sickle cell disease inhibitor, uses its aldehyde group to reversibly form a Schiff base with Val1 amino group on hemoglobin's beta chain. This stabilizes hemoglobin's R-state via intramolecular hydrogen bonds, boosting oxygen affinity. Optimized pretreatment overcomes extremely low extraction recovery of Schiff-Base forming reversible covalent compounds in whole blood.
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Development of an Automatic Immunocapture-Based Integrated Mass Spectrometry Platform for Qualitative and Quantitative Study of Fusion Protein Drug
Therapeutic peptide drugs demonstrate significant clinical potential due to their high specificity, strong target affinity, and superior tissue permeability. However, their short half-life often leads to rapid systemic clearance. To overcome these limitations, several strategies have been developed to prolong half-life and enhance efficacy, such as Fc-fusion and antibody conjugation, and so on. In particular, with the increasing application of GLP-1-based fusion proteins in treating obesity and diabetes, understanding and optimizing their pharmacokinetic properties is essential.
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Determination of DS-8201 in Rat Plasma Using mSPE Magnetic Beads Method Coupled with Liquid Chromatography-Tandem Mass Spectrometry
Magnetic SPE (mSPE) beads are composed of magnetic cores coated with polymer adsorbent materials, such as HLB and MCX. By capturing and enriching trace amounts of target analytes in the sample matrix, these beads can overcome the shortcomings of clogging and complicated operation associated with traditional solid-phase extraction cartridges. They make the separation and concentration process simple, fast, and efficient. Compared with traditional SPE, mSPE increases efficiency by more than 30% and reduces costs by over 90%.
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An Integrated Mass Spectrometry-Based Platform for the Multiplexed Quantification of Antibody-Oligonucleotide Conjugates (AOCs)
By exploiting the antigen-binding specificity of antibodies, AOCs enable precise delivery of oligonucleotide payloads to tissues and cells that are difficult to reach with conventional oligonucleotide therapies, thereby expanding the therapeutic landscape to rare muscular diseases, cancers, and central‑nervous‑system disorders. It is crucial to characterize the ADME properties of AOCs to optimize their distribution in target tissues and to understand their PK/PD properties. However, the complexity of the AOC structure presents significant challenges for bioanalysis. In this study, we established an integrated mass spectrometry platform to support the bioanalysis of AOCs drug.
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Investigation Strategies of the ADC Payload with the Thiol Group in In Vivo Samples
After ADC payload or payload-linker is cleaved in vivo by enzymes, for the payloads bearing thiol groups, they will not exist simply as “conjugated to antibody” or “free” species. Instead, they can be present in multiple forms due to the disulfide bond: the free payload, payload–protein adducts, payload dimers, and payload–cysteine adducts. Determining what payload species are present in target tissues and the concentration of each is critical for understanding the actual effect of the designed ADC and guiding its clinical use. In this study, experiments were designed to characterize payload–protein adducts and to identify and accurately quantify each species using LC–MS/MS and LC–HRMS.
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LLOQ Enhancement: A Case Study of LC-MS/MS Quantification for a Peptide in Dog Plasma
For peptide therapeutics administered via non-intravenous routes, they typically exhibit low systemic exposure due to their high polarity and molecular weight, limiting membrane permeability. Therefore, method development must prioritize high analytical sensitivity. Even with LC‑MS/MS, peptide plasma analysis is challenged by non‑specific binding, multiply charged ions, and poor extraction recovery, which all lead to a reduction in analytical sensitivity. To address these issues, we report a peptide case study in dog plasma in which mass spectrometry parameters, LC conditions, and sample extraction procedures were systematically optimized to demonstrate improvements in method sensitivity.
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A Novel and Efficient LC-MS/MS Method for Quantitation of Polysarcosine in Mouse Plasma
Assessing pSar's plasma stability is crucial to prevent off-target effects, enhancing efficacy and safety. Unlike traditional small molecules, pSar's multiple sarcosine (N-methylglycine) units linked by amide bonds result in variable molecular weight, complicating Q1 ion selection in liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis. Multiple positive charges contribute to non-specific binding (NSB) and severe peak tailing during sample extraction and analysis. We are the first to establish a rapid LC-MS/MS method for pSar with an average molecular weight of ~12,000 Da, overcoming all previous challenges to enable rapid assessment of pSar stability in mouse plasma.
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Novel LC-Orbitrap Method for Quantifying De Novo Lipogenesis: Applications in Circadian Rhythms and Nutritional States in SD Rats
Measurement of DNL can provide insights into mechanisms and guide interventions if performed rapidly and noninvasively. DNL is calculated based on the measurement of newly synthesized palmitic acid and body water, typically using isotope tracers. The current method for determining DNL employs GC-Orbitrap, which offers superior isotope resolution but has limitations in instrument availability. In this study, we developed a fast, accurate, and convenient method for DNL determination using LC-Orbitrap, expanding the technical approaches available for DNL detection effectively.
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Comprehensive Characterization of ADC Biotransformation in In Vitro Plasma Using UPLC-HRMS
Here, we develop a UPLC-HRMS workflow to enable rapid, comprehensive profiling of ADC biotransformation in plasma. This approach simultaneously captures intact ADC or subunits, payload-conjugated components, and payload-related metabolites, facilitating stability assessment and mechanistic insight into ADC catabolic routes.
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A Robust LC–MS/MS Method for Quantitative Bioanalysis of siRNA Antisense Strand in Mouse Serum and Liver
In this work, a robust and selective LC–MS/MS method was developed for the quantification of the antisense strand of a siRNA in mouse serum and liver homogenate. The assay was performed on a Triple Quad 6500+ mass spectrometer using negative electrospray ionization and multiple reaction monitoring. Chromatographic separation was achieved using ion-pair reversed-phase UPLC with hexafluoroisopropanol (HFIP) and diisopropylethylamine (DIPEA) on a peptide BEH C18 column. Nusinersen was employed as a structurally relevant internal standard to control extraction efficiency and instrumental variability.
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View More -
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Bioanalysis Publication: An Ultra-Sensitive UPLC-MS Method for ADC Payload Analysis Developed by WuXi AppTec DMPK
ArticlesMay 14,2026
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Application of Acoustic Ejection Mass Spectrometry for Plasma Protein Binding Assay Using Flux Dialysis
PublicationsApr 29,2026 -
ADC DAR Analysis: Qualitative & Quantitative Dual-Strategy for In Vivo Profiling丨DMPK Frontiers
VideosApr 23,2026
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