Establishment and Characterization of an In vitro Model for NTCP Substrate and Inhibition Assessment

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May 06,2024

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NTCP (Sodium taurocholate co-transporting polypeptide) is encoded by the solute carrier family 10 member 1 (SLC10A1) gene, which is mainly located on the basolateral membrane of human hepatocytes and a mediator of bile acid transport. NTCP is also identified as the receptor responsible for the cellular entry of hepatitis B virus (HBV) and hepatitis D virus (HDV), mediating virus invasion into hepatocytes. In recent years, the development of virus entry inhibitors targeting NTCP has become the mainstream of liver drug development. The purpose of this study is to set up an in vitro model to screen NTCP substrates and inhibitors to support NTCP targeting drug development and evaluate NTCP related drug-drug interactions.

Establishment and Characterization of an In vitro Model for NTCP Substrate and Inhibition Assessment

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