Conferences
73rd ASMS Conference on Mass Spectrometry and Allied Topics
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June 1 - 5, 2025
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Baltimore Convention Center, Baltimore, Maryland
The American Society for Mass Spectrometry (ASMS) was formed in 1969 to promote and disseminate knowledge of mass spectrometry and allied topics. Membership includes over 8,500 scientists involved in research and development. Members come from academic, industrial and governmental laboratories. Their interests include advancement of techniques and instrumentation in mass spectrometry, as well as fundamental research in chemistry, geology, forensics, biological sciences and physics.
ASMS sponsors the Annual Conference on Mass Spectrometry and Allied Topics that is attended by more than 6,500 scientists. Over 3,000 papers are presented as posters and talks.
Our posters
Other Resources
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Our posters -
Other Resources
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Construction of a UPLC-UPC2-MS/MS Platform
By integrating the characteristics of UPLC and UPC2, our laboratory has developed a UPLC-UPC2-MS/MS system. This system allows for the simultaneous on-line use of UPLC and UPC2 with the same mass spectrometer, enabling rapid online switching between UPLC-MS/MS and UPC2-MS/MS within 2 minutes. Additionally, the system allows for simultaneous control of both UPLC and UPC2, which can further extend the usage of MS and save instrument cost.
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An Efficient and Environmentally Friendly Method for Determination of Nucleoside Phosphate Compounds by LC-MS/MS
Nucleoside-based drugs, recognized as purine or pyrimidine analogs, are potent therapeutic agents specifically used for the treatment of viral infections. These drugs exhibit complex interactions with cellular molecular constituents, primarily via activation of phosphorylation cascades leading to consequential interactions with nucleic acids. Determination of nucleoside mono-, di- and triphosphates (NMP, NDP, and NTP) and their deoxy-counterparts (dNMP, dNDP, dNTP), can intuitively reflect the mechanisms of action and efficacy of these drugs.
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Bioanalytical Strategy for Payloads of Antibody Drug Conjugates (ADCs) with LC-MS Platform
After administration, ADCs can exist in various forms in the body, including intact ADCs, biotransformation products, free payloads, linker-payload conjugates, and related metabolites. Pharmacokinetic studies of ADCs typically require the assessment of total antibodies, conjugated antibodies, free payloads, drug-to-antibody ratios (DAR), conjugated payloads, drug linkers, relevant metabolites, and the immunogenicity of the ADCs. A variety of bioanalytical platforms are needed to understand the actual role of ADCs in disease, including ELISA, LC-HRMS, and LC-MS/MS.
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Development of a High-throughput and Cost-effective Method for Experimental Polar Surface Area Measurement with Ultra-Performance Convergence Chromatography Tandem Mass Spectrometry
Topological polar surface area (TPSA) is a calculated value defined as the total surface area of polar atoms (usually oxygen, nitrogen, and attached hydrogen) in a molecule. Experimental polar surface area (EPSA) is different from TPSA, which is determined based on the chromatographic retention of the molecule. EPSA is a key physical property to understand the bioavailability of drugs. In this study, a high-throughput and cost-effective ultra-performance convergence chromatography tandem mass spectrometry (UPCC-MS/MS) assay was developed to understand the permeability of drug candidates.
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Optimization of Sample Pretreatment Methods for LC-MS/MS Determination of Oligonucleotide Drugs in Tissues and Excreta
Liquid-liquid extraction (LLE), due to its low cost and simple operation, is commonly used for oligonucleotide extraction in biomatrices. However, it co-extracts endogenous inorganic salts and acids in tissue and excretion samples, leading to matrix effects and bad peak shape.
This study compares solid-phase extraction (SPE) and LLE, establishing a general, rapid, robust method to solve common LLE issues.
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Ultimate Exploration of the LLOQ of Exatecan, a Common Antibody Drug Conjugate (ADC) Payload
Exatecan, a derivative of camptothecin, is commonly used as ADC payload for anti-tumor activity. Camptothecin drugs, given their unique lactone ring-containing structure, exhibit different molecular forms (open-ring and closed-ring forms) under acidic and basic conditions, and when detected using liquid chromatography-tandem mass spectrometry (LC-MS/MS), result in different elution time and m/z. Here, we established a simple, accurate, highly sensitive, and robust LC-MS/MS method in preclinical stages to measure camptothecin drugs such as extecan.
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An LC-MS/MS Method for Separation and Quantification of Chiral Molecules
Stereoisomerism is common in organic chemistry. Some isomers can be identified by mass spectrum, whereas, others like enantiomer or cis-trans-isomer because of the same fragmentation pattern, have to be isolated by liquid chromatogram. In the pharmaceutical industry, about 60% of the drugs currently in use are chiral drugs which most approved chiral drugs are single enantiomers and a small part are racemes. Chiral drugs have attracted much attention from drug regulators and drug developers because of their special differences in pharmacology, toxicology, and pharmacokinetics in vivo.
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A Robust Method for Detection of Covalent Drugs in Mouse Blood
Covalent drugs have gained widespread attention in drug discovery for the successful treatment of a variety of diseases such as lymphoma, lung, and breast cancer. The covalent binding to proteins such as albumin, acid glycoprotein, globulin, and various lipoproteins presents challenges for the bioanalysis of covalent drugs. Due to the time-dependent covalent binding process in whole blood, the longer the sample is stored, the higher the covalent binding will be. Additionally, the test compound continuously releases from the precipitate to supernatant during protein precipitation pretreatment. Both will affect sample analysis.
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A Novel Validated LC-MS/MS Approach for Survodutide in Mouse Liver
Survodutide is a potent, acylated peptide that incorporates a C18 fatty acid to extend its half-life. This approach addresses the issue of extracting liver tissue samples by optimizing the homogenate. Furthermore, it resolves the problem of reproducibility of chromatographic peaks by purifying the samples using Protein Precipitation (PPT) and Solid Phase Extraction (SPE).
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An Ultra-High Throughput Method for 13C6-Fructose-6-Phosphate in Cells Using Acoustic Ejection Mass Spectrometry (AEMS)
As an endogenous compound, F6P is subject to endogenous interference. Isotopic-labeled compound 13C6-F6P is used to reduce endogenous interference and enhance specificity. The traditional LC-MS/MS method for 13C6-F6P is complex and time-consuming, often requiring derivatization, ion-pair reagents, pH adjustments of complex mobile phases, or other lengthy procedures, making them unsuitable for high-throughput screening (HTS). This study describes an ultra-high throughput method for detecting 13C6-F6P in cell matrices using AEMS technology. This method is rapid, high-throughput, sensitive, and reliable, aiding F6P-targeted PFKP research.Glucose-based aerobic glycolysis, also known as the Warburg effect, supplies energy for rapid tumor growth. The phosphorylation of fructose-6-phosphate (F6P) by phosphofructokinase-1 (PFK1) is a key rate-limiting step in the Warburg effect and a target for cancer therapy.
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Bioanalytical Strategy for Quantitative Conjugated Payloads of Antibody-Drug Conjugates (ADCs) with Cleavable Linker
Currently, out of sixteen approved ADCs on the global market, 13 ADCs have cleavable linkers, including protease-cleavable linkers, reduction linkers, and pH-sensitive linkers. This study took these three types of cleavable linkers as examples to establish a rapid, high-throughput, sensitive, and reliable liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for conjugated payload quantification, which was successfully applied to in vivo PK rat serum sample analysis.
View More -
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Streamlining the Bioanalysis of Antibody-Drug Conjugates (ADCs): Simultaneous Determination of Total Antibodies and Conjugated Payloads
ArticlesMar 04,2025
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Introduction to Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and Its Applications in Bioanalysis
ArticlesFeb 26,2025 -
Antibody-Drug Conjugate (ADC) Preclinical PK/PD Study Strategies and Practices
ArticlesFeb 19,2025
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