AAPS Webinar: Tackling the CNS Drug Challenges with DMPK Toolkit for Exposure, Stability, and Metabolism

Webinar Overview:

Central Nervous System (CNS) drug development faces unique challenges, driven by evolving trends in neuroscience, complex disease mechanisms, and the critical need for blood-brain barrier (BBB) penetration. As therapeutic innovation accelerates, understanding the role of Drug Metabolism and Pharmacokinetics (DMPK) has become indispensable for optimizing efficacy and safety.

This webinar explores recent trends shaping CNS drug discovery, emphasizing why robust DMPK strategies are essential to CNS drug development. We will introduce how to select and apply in vitro models and in vivo PK studies to assess CNS-specific parameters, including stability, metabolism, permeability, and target exposure. We will also discuss tailored strategies for integrating these assessments into development pipelines, accelerating the delivery of transformative CNS therapies.

Learning Objectives:

• Recent trends and developments shaping CNS drug development.

• Why DMPK is essential for CNS drug development.

• How to select and apply the right in vitro and in vivo PK models to perform stability, metabolism, permeability, and exposure assessments for CNS drugs.

• Practical strategies to integrate CNS DMPK data into discovery-to-IND decision making.