C&EN Webinars: Integrated Platform for Peptide Radiolabeling Synthesis and In Vivo ADME Research

Webinars Overview

In recent years, peptide therapeutics have garnered significant attention due to their remarkable potential in treating a wide range of human diseases, including diabetes, obesity, and cancer. Over 100 peptide drugs have been approved and marketed globally, highlighting their growing importance in modern medicine. However, the development of novel peptide therapeutics is not without challenges. Their increased size and   structural complexity pose unique difficulties in bioanalysis, such as non-specific binding, assay sensitivity, stability, and immunogenicity evaluations. Additionally, the diverse submodalities of therapeutic peptides   result in distinct ADME properties, which further complicate their preclinical development. Given the lack of specific guidelines and technical   standards for non-clinical research on peptide drugs, a case-by-case approach is essential for preclinical toxicological evaluations. This involves   designing studies based on the specific regulations outlined in various guidelines while considering the unique characteristics of each peptide drug. To address these challenges and accelerate the development process,   comprehensive preclinical development, DMPK, and bioanalytical solutions are crucial.

This webinar will cover non-clinical safety evaluation strategies,   DMPK assessment methods like peptide radiolabeling and metabolite profiling,   as well as solutions for bioanalytical challenges such as non-specific   binding and immunogenicity, providing researchers with essential knowledge and tools.

Different from small molecules and large proteins, the diverse submodalities of therapeutic peptides have distinct structures and carry different absorption, distribution, metabolism, and excretion (ADME) properties. In this webinar, experts from WuXi AppTec will share essential strategies for accelerating DMPK assessments of peptides, developed at a late stage. During the webinar, methodologies of peptide radiolabeling positions, complete excretion recovery, as well as metabolite profiling and identification for modified amino acid or fatty acid chains will be addressed.

Learning Objectives:

1. Peptide radiolabeling synthesis considerations.

2. Pre-clinical peptide ADME research experiences in rodents and large animals.

3. Late-stage DMPK strategies for novel therapeutics