Integrated Strategies to Accelerate Pre-Clinical Development of Antibody-Drug Conjugates

Antibody-drug conjugates (ADCs) hold great promise as targeted cancer therapeutics. But their complex structure poses significant development and safety challenges for biopharma.

In this GEN webinar, experts from WuXi AppTec will share essential strategies and methodologies for accelerating pre-clinical assessments of ADCs. This will include approaches for assessing the pharmacology, biotransformation, toxicokinetics, and immunogenicity of biologics early in their development. The webinar will offer methods for addressing ADC resistance as well as for metabolite profiling and identifying payload-related species for cleavable and non-cleavable ADCs.

In this webinar you’ll learn:

The complex biotransformation processes of ADCs and detailed methodologies for metabolite profiling of payload-related species and Drug-to-Antibody Ratio distribution