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Sample Chapter: Proteolysis-Targeting Chimeras (PROTACs) from Drug Metabolism and Pharmacokinetics: Frontiers, Strategies, and Applications

  • Publications

  • June 06,2025

Publications Overview

Utilizing the body’s natural protein degradation mechanism, proteolysis-targeting chimeras (PROTACs) can access previously inaccessible proteins and treat diseases. This chapter provides an in-depth exploration of the structure and mode of action of PROTACs and various strategies that have been employed to improve the oral bioavailability of PROTACs. The chapter also discusses the metabolic characteristics and research strategies for identifying their metabolites, evaluates potential drug-drug interactions involving efflux transporters, and addresses the challenges and strategies in preclinical bioanalysis of PROTACs.

Sample Chapter: Proteolysis-Targeting Chimeras (PROTACs) from Drug Metabolism and Pharmacokinetics: Frontiers, Strategies, and Applications

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