A Comprehensive Platform for Evaluating the In Vitro CYP Reaction Phenotyping of New Molecular Entities (NME)

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September 26,2024

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Although the non-CYP enzymes are frequently involved in the elimination of many drugs, CYP still is the major enzyme involved in metabolic clearance. Careful assessment of the contribution of individual CYP toward the overall metabolism of a new molecular entity (NME) is therefore crucial to accurately assess the object DDI liability of an NME in the clinic.

A Comprehensive Platform for Evaluating the In Vitro CYP Reaction Phenotyping of New Molecular Entities (NME).jpg

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