Human Pharmacokinetics Prediction for Trastuzumab Using Scaling and Two-Compartment Modeling with B-hFcRn Mice PK Data

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September 12,2025

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Biocytogen humanized neonatal Fc receptor mice (B-hFcRn mice) offer an alternative model for Tg32 mice in pharmacokinetic studies of biologics; however, differences between B-hFcRn and Tg32 mice raise uncertainties about whether data from B-hFcRn mice can reliably predict human pharmacokinetics.

Human Pharmacokinetics Prediction for Trastuzumab Using Scaling and Two-Compartment Modeling with B-hFcRn Mice PK Data

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