Enhancing Oral Bioavailability in Preclinical Dog PK Studies Using Ball Milling Technology
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Posters
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September 12,2025
Posters Overview
Ball milling technology has the potential to enhance the oral bioavailability of poorly soluble drugs by reducing particle size, which can lead to improved systemic exposure in vivo. For heat-sensitive drugs, it is important to use intermittent milling and controlled speed to prevent degradation. We have evaluated a series of dispersants to ensure stability and proper particle size for nanometer suspension. Selecting the appropriate stabilizer and carefully considering critical instrument parameters are crucial steps in preparing effective nanometer suspensions. In summary, the careful selection of dispersants and the optimization of milling parameters are essential for preparing high-performance nanometer suspensions.
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