Application of Lecithin (PL90) and Poloxamer 188 in SLC Transporter-Mediated Drug Interaction Studies

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September 12,2025

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Solute Carrier (SLC) transporter-mediated drug interaction studies are essential in drug development. However, poor solubility and/or non-specific binding issues of highly lipophilic compounds pose significant challenges in in vitro research. Pharmaceutical excipients such as lecithin (PL90) and poloxamer 188 can improve solubility and/or reduce non-specific binding of highly lipophilic compounds. This study aimed to evaluate the effects of PL90 and poloxamer 188 on SLC transporter activities and to establish a good method for assessing transporter-mediated drug interaction studies of highly lipophilic compounds.

Application of Lecithin (PL90) and Poloxamer 188 in SLC Transporter-Mediated Drug Interaction Studies

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