The Application of Bile Duct Cannulation Animal Models in Radiolabeled Preclinical ADME Studies

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September 11,2025

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Radiolabeled absorption, distribution, metabolism, and excretion (ADME) studies in preclinical species (rodent and large animal) generate comprehensive quantitative profiles of drug disposition, delineating metabolic pathways and excretion patterns across plasma, bile, urine, and faeces. As a critical methodology of excretion characterisation, bile duct cannulation (BDC) studies utilise surgical cannulation models to quantify biliary elimination (expressed as % of administered dose) and achieve three key objectives: Mechanistic confirmation of enterohepatic recirculation pathways; Structural elucidation of major biliary metabolites; Bioavailability assessment through urinary and biliary excretion data.

The Application of Bile Duct Cannulation Animal Models in Radiolabeled Preclinical ADME Studies

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