Optimisation of an In Vitro Plated Monkey Hepatocyte Model and Comparative Metabolite Profiling of a GalNAc-Conjugated siRNA, siRNA01, in Monkey Liver Homogenate and Hepatocytes

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September 26,2025

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In this study, the culture conditions for plated monkey hepatocytes were optimised by adjusting cell density and evaluating different lots of hepatocytes from multiple vendors. After optimising conditions, the expected metabolism profile for our model compound, siRNA01, a commercially available GalNAc-conjugated siRNA, was obtained. Furthermore, comparative metabolite profiling of siRNA01 in optimised plated monkey hepatocytes and monkey liver homogenate revealed highly similar profiles.

Optimisation of an In Vitro Plated Monkey Hepatocyte Model and Comparative Metabolite Profiling of a GalNAc-Conjugated siRNA, siRNA01, in Monkey Liver Homogenate and Hepatocytes

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